Mitochondrial noncoding RNA transport

Mitochondrial noncoding RNA transport

Mitochondria are cytosolic organelles essential for generating energy and maintaining cell homeostasis. Despite their critical function, the handful of proteins expressed by the mitochondrial genome is insufficient to maintain mitochondrial structure or activity. Accordingly, mitochondrial metabolism is fully dependent on factors encoded by the nuclear DNA, including many proteins synthesized i...

LIPCAR: a mitochondrial lnc in the noncoding RNA chain?

All proteins are translated from RNA, but only a fraction of RNAs seem to be translated into proteins. Advanced genomics technologies have uncovered noncoding regulatory RNAs exhibiting extraordinary diversity in size, structure, and molecular function. We know a great deal about small (≈20 nucleotides) microRNAs that post-transcriptionally regulate translation of protein from target mRNAs havi...

Long noncoding RNA Tug1 regulates mitochondrial bioenergetics in diabetic nephropathy.

The regulatory roles of long noncoding RNAs (lncRNAs) in transcriptional coactivators are still largely unknown. Here, we have shown that the peroxisome proliferator-activated receptor γ (PPARγ) coactivator α (PGC-1α, encoded by Ppargc1a) is functionally regulated by the lncRNA taurine-upregulated gene 1 (Tug1). Further, we have described a role for Tug1 in the regulation of mitochondrial funct...

Long Noncoding RNA-GAS5

Long Noncoding RNA Enriched −

Robert D. Bell, Xiaochun Long, Mingyan Lin, Jan H. Bergmann, Vivek Nanda, Sarah L. Long Noncoding RNA Enriched − Identification and Initial Functional Characterization of a Human Vascular Cell Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2014 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 727...